| EDITORIAL | 5 |
| CARDIOVASCULAR TOPICS | 6 |
| The prevalence and distribution of non-communicable diseases and their risk factors in Kasese district, Uganda | 6 |
| Modulation of haemodynamics, endogeneous antioxidant enzymes, and pathophysiological changes by selective inhibition of angiotensin II type 1 receptors in pressureoverload rats | 12 |
| Hypertension and associated factors in older adults in South Africa | 20 |
| Neonatal circulatory failure due to acute hypertensive crisis: clinical and echocardiographic clues | 26 |
| Decreased vascular contractility induced by hemin is associated with a reduced rho-kinase activity | 30 |
| Cardiovascular complications in newly diagnosed rheumatic heart disease patients at Mulago Hospital, Uganda | 34 |
| LETTER TO THE EDITOR | 19 |
| REVIEW ARTICLE | 40 |
| CARDIO NEWS | 47 |
| DRUG TRENDS IN CARDIOLOGY | 49 |
| South African studies in the international literature | 49 |
| Higher statin doses linked to acute kidney injury: South African experts comment on clinical implications | 51 |
| Treating hypertension in the elderly, even white-coat hypertension, is essential | 52 |
| Use new antiplatelet therapies consistently in clinical practice | 54 |
| CASE REPORTS - PUBLISHED ONLINE | 55 |
| Left ventricular non-compaction in pregnancy | 55 |
| Unusual variant of scimitar syndrome associated with an absent right pulmonary artery, stenosis of the inferior vena cava, hemi-azygous continuation and the VACTERL association | 57 |
| Candida parapsilosis endocarditis on a prosthetic aortic valve with unclear echocardiographic features | 61 |
| Robotically assisted ventricular tachycardia substrate modification ablation with the novel LynxTM integrated sheath and RF ablation catheter | 63 |
| Unexpected preserved brain perfusion imaging despite severe and diffuse atherosclerosis of supra-aortic trunks | 66 |